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MetaCell MC 40 is an R package that partitions single-cell RNA-seq data into homogeneous metacells, facilitating detailed exploration of cellular heterogeneity and gene expression patterns.
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The MetaCell MC 40 is a specialized R package designed for the analysis of single-cell RNA sequencing (scRNA-seq) data. It facilitates the partitioning of a cell similarity graph into small, homogeneous groups of cells, termed metacells, typically comprising 20-200 cells. These metacells serve as robust units for downstream analyses, enabling researchers to identify cell types, subtypes, transcriptional gradients, cell-cycle variations, gene modules, and their regulatory models. The MC 40 version incorporates significant algorithmic improvements, enhancing scalability to analyze datasets comprising millions of cells.
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